TY - JOUR T1 - What is the optimal dosage of linezolid in treatment of complicated multidrug-resistant tuberculosis? JF - European Respiratory Journal JO - Eur Respir J SP - 1492 LP - 1494 DO - 10.1183/09031936.00111009 VL - 34 IS - 6 AU - W. W. Yew AU - K. C. Chang AU - C. H. Chau Y1 - 2009/12/01 UR - http://erj.ersjournals.com/content/34/6/1492.abstract N2 - To the Editors: In a retrospective study, Migliori et al. 1 have elegantly shown that linezolid 600 mg daily or twice daily added to an individualised multidrug regimen was efficacious in treating multidrug-resistant tuberculosis (MDR-TB). Once-daily dosing was associated with less major adverse effects than twice-daily dosing, corroborating the results of an earlier study in South Korea 2. As a result of the potentially serious side-effects, Migliori et al. 1 have appropriately recommended reserving linezolid treatment for the most complicated cases of MDR-TB. We concur with these views and would like to share our experience … ER -