PT  - JOURNAL ARTICLE
AU  - P. A. J. Crosbie
AU  - M. A. Woodhead
TI  - Long-term macrolide therapy in chronic inflammatory airway diseases
AID  - 10.1183/09031936.00042208
DP  - 2009 Jan 01
TA  - European Respiratory Journal
PG  - 171--181
VI  - 33
IP  - 1
4099  - http://erj.ersjournals.com/content/33/1/171.short
4100  - http://erj.ersjournals.com/content/33/1/171.full
SO  - Eur Respir J2009 Jan 01; 33
AB  - In addition to direct antibacterial actions, 14- and 15-member-ring macrolides have immune modulating effects that appear to be the reason for clinical benefit in diffuse panbronchiolitis. A literature search was conducted for studies of the clinical effectiveness of macrolides in other chronic lung conditions. A number of studies were identified that showed short-term beneficial outcomes or the potential for such outcomes in cystic fibrosis, bronchiectasis, chronic obstructive pulmonary disease, asthma and post-transplant obliterative bronchiolitis. The studies were limited by small patient numbers, different outcome measures and short-term follow-up, and were not designed to assess potentially harmful effects. Further large prospective and long-term studies are required in order to identify potential benefit and harm before these agents can be recommended routinely for these conditions.