RT Journal Article SR Electronic T1 Reversing the tuberculosis upwards trend: a success story in Romania JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 168 OP 170 DO 10.1183/09031936.00104308 VO 33 IS 1 A1 C. Marica A1 C. Didilescu A1 N. Galie A1 D. Chiotan A1 J. P. Zellweger A1 G. Sotgiu A1 L. D'Ambrosio A1 R. Centis A1 L. Ditiu A1 G. B. Migliori YR 2009 UL http://erj.ersjournals.com/content/33/1/168.abstract AB At present, no published evidence is available on the effectiveness of the DOTS (directly observed treatment, short-course) strategy in reducing the incidence of tuberculosis (TB) within a country in the European “hot spots”. The present study aimed to demonstrate the effectiveness of the strategy implementation in reversing the epidemiological TB trend in Romania based on programmatic data analysis. Key programme indicators were analysed from 1998 to 2007, and included DOTS coverage, case-detection rate, treatment success and overall incidence of notified cases. Internationally agreed definitions were used. The key programme indicators began declining and the World Health Assembly targets were reached (79% case-detection of new sputum-smear positive cases and 85.5% success rate in new culture-positive TB cases), 7 yrs after initiation of the DOTS expansion. The success story in Romania suggests that other middle-income, high-incidence countries (i.e. those belonging to the former Soviet Union) might be able to reach the World Health Assembly Targets and curb the burden of tuberculosis.