RT Journal Article
SR Electronic
T1 Tuberculosis and airflow obstruction: evidence from the PLATINO study in Latin America
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1180
OP 1185
DO 10.1183/09031936.00083507
VO 30
IS 6
A1 A. M. B. Menezes
A1 P. C. Hallal
A1 R. Perez-Padilla
A1 J. R. B. Jardim
A1 A. Muiño
A1 M. V. Lopez
A1 G. Valdivia
A1 M. Montes de Oca
A1 C. Talamo
A1 J. Pertuze
A1 C. G. Victora
A1 for the Latin American Project for the Investigation of Obstructive Lung Disease (PLATINO) Team
YR 2007
UL http://erj.ersjournals.com/content/30/6/1180.abstract
AB The aim of the present study was to evaluate the association between history of tuberculosis and airflow obstruction. A population-based, multicentre study was carried out and included 5,571 subjects aged ≥40 yrs living in one of five Latin American metropolitan areas: Sao Paulo (Brazil); Montevideo (Uruguay); Mexico City (Mexico); Santiago (Chile); and Caracas (Venezuela). Subjects performed pre- and post-bronchodilator spirometry and were asked whether they had ever been diagnosed with tuberculosis by a physician. The overall prevalence of airflow obstruction (forced expiratory volume in one second/forced vital capacity post-bronchodilator <0.7) was 30.7% among those with a history of tuberculosis, compared with 13.9% among those without a history. Males with a medical history of tuberculosis were 4.1 times more likely to present airflow obstruction than those without such a diagnosis. This remained unchanged after adjustment for confounding by age, sex, schooling, ethnicity, smoking, exposure to dust and smoke, respiratory morbidity in childhood and current morbidity. Among females, the unadjusted and adjusted odds ratios were 2.3 and 1.7, respectively. In conclusion, history of tuberculosis is associated with airflow obstruction in Latin American middle-aged and older adults.