RT Journal Article
SR Electronic
T1 Increased urinary leukotriene E<sub>4</sub> concentration in patients with eosinophilic pneumonia
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 437
OP 442
DO 10.1183/09031936.00093407
VO 32
IS 2
A1 E. Ono
A1 M. Taniguchi
A1 H. Mita
A1 N. Higashi
A1 Y. Fukutomi
A1 H. Tanimoto
A1 K. Sekiya
A1 C. Oshikata
A1 T. Tsuburai
A1 N. Tsurikisawa
A1 M. Otomo
A1 Y. Maeda
A1 O. Matsuno
A1 E. Miyazaki
A1 T. Kumamoto
A1 K. Akiyama
YR 2008
UL http://erj.ersjournals.com/content/32/2/437.abstract
AB Although eosinophils produce cysteinyl leukotrienes (CysLTs) in large quantities, information on the relationship between CysLTs and eosinophilic pneumonia (EP) is lacking. Inflammatory mediator concentrations in urine were quantified to clarify the relationship between CysLT concentrations and EP severity. Leukotriene (LT)E4, eosinophil-derived neurotoxin (EDN), 9α,11β-prostaglandin F2 and LTB4 glucuronide concentrations were quantified in the urine of: EP patients during acute exacerbation and clinical remission; asthmatic patients during acute exacerbation and under stable conditions; and healthy control subjects. The urinary LTE4 and EDN concentrations of EP patients during acute exacerbation were significantly higher than those of asthmatic patients and healthy subjects, and decreased immediately during clinical remission. The urinary LTE4 concentration was associated with the urinary EDN concentration of EP patients during acute exacerbation. The urinary LTE4 concentration significantly correlated with the diffusing capacity of the lung for carbon monoxide in EP patients during acute exacerbation. The increased urinary concentrations of leukotriene and eosinophil-derived neurotoxin were associated with acute exacerbation in eosinophilic pneumonia patients. The increased leukotriene concentration significantly correlated with diffusing capacity of the lung for carbon monoxide, suggesting that the monitoring of leukotriene concentration may aid in the management of eosinophilic pneumonia patients.