TY - JOUR T1 - Magnetic resonance-compatible-spirometry: principle, technical evaluation and application JF - European Respiratory Journal JO - Eur Respir J SP - 972 LP - 979 DO - 10.1183/09031936.00040607 VL - 30 IS - 5 AU - M. Eichinger AU - M. Puderbach AU - H-J. Smith AU - R. Tetzlaff AU - A. Kopp-Schneider AU - M. Bock AU - J. Biederer AU - H-U. Kauczor Y1 - 2007/11/01 UR - http://erj.ersjournals.com/content/30/5/972.abstract N2 - The aim of this study was to assess the feasibility and accuracy of a novel magnetic resonance-compatible (MRc)-spirometer. The influence of body posture, magnetic resonance (MR)-setting and image acquisition on lung function was evaluated. Dynamic MR imaging (dMRI) was compared with simultaneously measured lung function. The development of the MRc-spirometer was based on a commercial spirometer and evaluated by flow-generator measurements and forced expiratory manoeuvres in 34 healthy nonsmokers (17 females and 17 males, mean age 32.9 yrs). Mean differences between forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were calculated and a sample paired t-test and Bland–Altman plots were generated. A total of 11 subjects underwent different subsequent MRc-spirometric measurements to assess the influence of the components of the MR system on lung function. The mean (95% confidence interval) difference of FEV1 and FVC between the two systems was 0.004 (-0.04–0.04) L and 0.018 (-0.05–0.09) L, respectively. In the subgroup analysis, an influence of the MR-system on FEV1 was found. FEV1 correlated well with the dMRI measurement of the apico-diaphragmatic distance-change after the first second of forced expiration (r = 0.72). In conclusion, magnetic resonance-compatible-spirometry is feasible, reliable and safe. The magnetic resonance-setting only has a small influence on simultaneously measured forced expiratory volume in one second. Dynamic magnetic resonance imaging measurements correlate well with simultaneously acquired lung function parameters. ER -