RT Journal Article
SR Electronic
T1 Angiotensinogen gene G-6A polymorphism influences idiopathic pulmonary fibrosis disease progression
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1004
OP 1008
DO 10.1183/09031936.00015808
VO 32
IS 4
A1 M. Molina-Molina
A1 A. Xaubet
A1 X. Li
A1 A. Abdul-Hafez
A1 K. Friderici
A1 K. Jernigan
A1 W. Fu
A1 Q. Ding
A1 J. Pereda
A1 A. Serrano-Mollar
A1 A. Casanova
A1 E. Rodríguez-Becerra
A1 F. Morell
A1 J. Ancochea
A1 C. Picado
A1 B. D. Uhal
YR 2008
UL http://erj.ersjournals.com/content/32/4/1004.abstract
AB Angiotensin II is a growth factor that plays a key role in the physiopathology of idiopathic pulmonary fibrosis (IPF). A nucleotide substitution of an adenine instead of a guanine (G-6A) in the proximal promoter region of angiotensinogen (AGT), the precursor of angiotensin II, has been associated with an increased gene transcription rate. In order to investigate whether the G-6A polymorphism of the AGT gene is associated with IPF development, severity and progression, the present study utilised a case–control study design and genotyped G-6A in 219 patients with IPF and 224 control subjects. The distribution of G-6A genotypes and alleles did not significantly differ between cases and controls. The G-6A polymorphism of the AGT gene was not associated with disease severity at diagnosis. The presence of the A allele was strongly associated with increased alveolar arterial oxygen tension difference during follow-up, after controlling for the confounding factors. Higher alveolar arterial oxygen tension changes over time were observed in patients with the AA genotype (0.37±0.7 mmHg (0.049±0.093 kPa) per month) compared to GA genotype (0.12±1 mmHg (0.016±0.133 kPa) per month) and GG genotype (0.2±0.6 mmHg (0.027±0.080 kPa) per month). G-6A polymorphism of the angiotensinogen gene is associated with idiopathic pulmonary fibrosis progression but not with disease predisposition. This polymorphism could have a predictive significance in idiopathic pulmonary fibrosis patients.