RT Journal Article
SR Electronic
T1 Systemic inflammation, genetic susceptibility and lung function
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 92
OP 97
DO 10.1183/09031936.00052507
VO 32
IS 1
A1 J. Sunyer
A1 R. Pistelli
A1 E. Plana
A1 M. Andreani
A1 F. Baldari
A1 M. Kolz
A1 W. Koenig
A1 J. Pekkanen
A1 A. Peters
A1 F. Forastiere
YR 2008
UL http://erj.ersjournals.com/content/32/1/92.abstract
AB Local inflammation in airway diseases is well recognised, but less is known about the association between low-grade systemic inflammatory processes and lung function. The aim of the present study was to assess the association between inflammatory markers and lung function, taking into account polymorphisms in genes coding for inflammatory markers. In 134 post-myocardial infarction patients, six repeated measurements of C-reactive protein (CRP), interleukin (IL)-6 and fibrinogen in peripheral blood were assayed using high-sensitivity tests. Spirometry was conducted at baseline. Genotyping of single nucleotide polymorphisms was performed in genes coding for the inflammatory markers. CRP and IL-6 levels were negatively associated with forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and mean forced expiratory flow between 25 and 75% of FVC (FEF25–75%). In the CRP gene, both the polymorphism rs1205 and the haplotype 2 showed a protective association with FEV1 and FEF25–75%, and, to a lesser extent, with FVC. rs1205 and haplotype 2 were both negatively associated with CRP levels in peripheral blood. Analysis with instrumental variables also showed a protective effect between these CRP gene polymorphisms and lung function. Results are very suggestive that heritability of lung function is at least partly controlled by the CRP gene. Applying a Mendelian randomisation approach, the study supports a causal association between low-grade general inflammation and airway diseases.