RT Journal Article
SR Electronic
T1 Acute respiratory distress syndrome secondary to antisynthetase syndrome is reversible with tacrolimus
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 213
OP 217
DO 10.1183/09031936.00014707
VO 31
IS 1
A1 S. Guglielmi
A1 T. M. Merz
A1 M. Gugger
A1 C. Suter
A1 L. P. Nicod
YR 2008
UL http://erj.ersjournals.com/content/31/1/213.abstract
AB Polymyositis and interstitial lung diseases, predominantly nonspecific interstitial pneumonia (NSIP), are known to be frequent in antisynthetase syndrome, where anti-aminoacyl-tRNA synthetase antibodies are often identified. An unusual case of acute respiratory distress syndrome, secondary to such proven NSIP of cellular type with predominant CD8 lymphocytes, is described herein. The patient described in the present case study initially had a poor recovery with high dose of steroids, but this was followed by a good improvement after the prescription of tacrolimus and a low dose of prednisone. A precise diagnosis in similar circumstances may be life-saving, allowing the successful application of new immunosuppressants.