TY - JOUR T1 - Acute respiratory distress syndrome secondary to antisynthetase syndrome is reversible with tacrolimus JF - European Respiratory Journal JO - Eur Respir J SP - 213 LP - 217 DO - 10.1183/09031936.00014707 VL - 31 IS - 1 AU - S. Guglielmi AU - T. M. Merz AU - M. Gugger AU - C. Suter AU - L. P. Nicod Y1 - 2008/01/01 UR - http://erj.ersjournals.com/content/31/1/213.abstract N2 - Polymyositis and interstitial lung diseases, predominantly nonspecific interstitial pneumonia (NSIP), are known to be frequent in antisynthetase syndrome, where anti-aminoacyl-tRNA synthetase antibodies are often identified. An unusual case of acute respiratory distress syndrome, secondary to such proven NSIP of cellular type with predominant CD8 lymphocytes, is described herein. The patient described in the present case study initially had a poor recovery with high dose of steroids, but this was followed by a good improvement after the prescription of tacrolimus and a low dose of prednisone. A precise diagnosis in similar circumstances may be life-saving, allowing the successful application of new immunosuppressants. ER -