TY - JOUR T1 - Polymorphisms in the type IV collagen α3 gene and the risk of COPD JF - European Respiratory Journal JO - Eur Respir J SP - 35 LP - 41 DO - 10.1183/09031936.00076207 VL - 32 IS - 1 AU - K. M. Kim AU - S. H. Park AU - J. S. Kim AU - W. K. Lee AU - S. I. Cha AU - C. H. Kim AU - Y. M. Kang AU - T. H. Jung AU - I. S. Kim AU - J. Y. Park Y1 - 2008/07/01 UR - http://erj.ersjournals.com/content/32/1/35.abstract N2 - A number of genome-wide linkage analyses have identified the 2q33.3–2q37.2 region as the most likely to contain the genes that contribute to the susceptibility to chronic obstructive pulmonary disease (COPD). It was hypothesised that the type IV collagen α3 (COL4A3) gene, which is one of the genes located in the 2q33.3–2q37.2 region, may act as a low-penetrance susceptibility gene for COPD. To test this hypothesis, the association of COL4A3 -1162T>C, IVS2+12C>A, P141L, G162E, H451R, P574L and *315C>A polymorphisms with the risk of COPD was investigated in a case–control study of 311 COPD patients and 386 controls. The presence of at least one 451R allele was associated with a significantly higher risk of COPD compared with the 451 H/H genotype (adjusted odds ratio 1.48, 95% confidence interval (1.03–2.14)). When the subjects were stratified according to age and COPD severity, the 451R allele was associated with a significantly higher risk of COPD only in younger individuals with severe COPD (3.02 (1.37–6.67)). In conclusion, these findings suggest that the type IV collagen α3 gene contributes to the genetic susceptibility to chronic obstructive pulmonary disease. ER -