TY - JOUR T1 - Exercise training reduces pulmonary ischaemia–reperfusion-induced inflammatory responses JF - European Respiratory Journal JO - Eur Respir J SP - 645 LP - 649 DO - 10.1183/09031936.00015607 VL - 31 IS - 3 AU - R. K. Mussi AU - E. A. Camargo AU - T. Ferreira AU - C. De Moraes AU - M. A. Delbin AU - I. F. C. Toro AU - S. Brancher AU - E. C. T. Landucci AU - A. Zanesco AU - E. Antunes Y1 - 2008/03/01 UR - http://erj.ersjournals.com/content/31/3/645.abstract N2 - Physical exercise reduces the deleterious effects of cardiovascular and inflammatory disorders. The purpose of the present study was to evaluate the beneficial effects of physical training on the inflammatory responses following lung ischaemia–reperfusion (IR) in rats. Male Wistar rats were divided into sham-operated animals and sedentary and trained animals submitted to lung IR. The run training programme consisted of 5 sessions·week−1, each lasting 60 min·day−1, at 66% of maximal oxygen consumption for 8 weeks. The left pulmonary artery, bronchus and pulmonary vein were occluded for 90 min and reperfused for 2 h. Lung protein extravasation was measured as 125I-human albumin accumulation, whereas lung neutrophil infiltration was measured as myeloperoxidase activity. Lung IR in sedentary rats resulted in marked increases in protein extravasation and neutrophil influx, and in significant elevations of serum tumour necrosis factor (TNF)-α and interleukin (IL)-1β levels. Physical preconditioning attenuated the increased IR-induced protein leakage without affecting neutrophil influx. It also reduced serum TNF-α (and IL-1β) levels, but had no effect on IL-10 levels. Plasma superoxide dismutase activity was significantly increased in trained IR rats. The present data show that physical preconditioning protects the rat lung from ischaemia–reperfusion injury by attenuating the pulmonary vascular permeability that may be a consequence of reduced levels of tumour necrosis factor-α and interleukin-1β and elevated superoxide dismutase activity. ER -