RT Journal Article
SR Electronic
T1 Exercise training reduces pulmonary ischaemia–reperfusion-induced inflammatory responses
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 645
OP 649
DO 10.1183/09031936.00015607
VO 31
IS 3
A1 R. K. Mussi
A1 E. A. Camargo
A1 T. Ferreira
A1 C. De Moraes
A1 M. A. Delbin
A1 I. F. C. Toro
A1 S. Brancher
A1 E. C. T. Landucci
A1 A. Zanesco
A1 E. Antunes
YR 2008
UL http://erj.ersjournals.com/content/31/3/645.abstract
AB Physical exercise reduces the deleterious effects of cardiovascular and inflammatory disorders. The purpose of the present study was to evaluate the beneficial effects of physical training on the inflammatory responses following lung ischaemia–reperfusion (IR) in rats. Male Wistar rats were divided into sham-operated animals and sedentary and trained animals submitted to lung IR. The run training programme consisted of 5 sessions·week−1, each lasting 60 min·day−1, at 66% of maximal oxygen consumption for 8 weeks. The left pulmonary artery, bronchus and pulmonary vein were occluded for 90 min and reperfused for 2 h. Lung protein extravasation was measured as 125I-human albumin accumulation, whereas lung neutrophil infiltration was measured as myeloperoxidase activity. Lung IR in sedentary rats resulted in marked increases in protein extravasation and neutrophil influx, and in significant elevations of serum tumour necrosis factor (TNF)-α and interleukin (IL)-1β levels. Physical preconditioning attenuated the increased IR-induced protein leakage without affecting neutrophil influx. It also reduced serum TNF-α (and IL-1β) levels, but had no effect on IL-10 levels. Plasma superoxide dismutase activity was significantly increased in trained IR rats. The present data show that physical preconditioning protects the rat lung from ischaemia–reperfusion injury by attenuating the pulmonary vascular permeability that may be a consequence of reduced levels of tumour necrosis factor-α and interleukin-1β and elevated superoxide dismutase activity.