RT Journal Article
SR Electronic
T1 Effects of edaravone, a free-radical scavenger, on bleomycin-induced lung injury in mice
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1337
OP 1343
DO 10.1183/09031936.00164407
VO 32
IS 5
A1 S. Tajima
A1 M. Bando
A1 Y. Ishii
A1 T. Hosono
A1 H. Yamasawa
A1 S. Ohno
A1 T. Takada
A1 E. Suzuki
A1 F. Gejyo
A1 Y. Sugiyama
YR 2008
UL http://erj.ersjournals.com/content/32/5/1337.abstract
AB Reactive oxygen species play an important role in the pathogenesis of acute lung injury and pulmonary fibrosis. The present authors hypothesise that edaravone, a free-radical scavenger, is able to attenuate bleomycin (BLM)-induced lung injury in mice by decreasing oxidative stress. Lung injury was induced in female ICR mice by intratracheal instillation of 5 mg·kg−1 of BLM. Edaravone (300 mg·kg−1) was administered by intraperitoneal administration 1 h before BLM challenge. Edaravone significantly improved the survival rate of mice treated with BLM from 25 to 90%, reduced the number of total cells and neutrophils in bronchoalveolar lavage fluid (BALF) on day 7, and attenuated the concentrations of lipid hydroperoxide in BALF and serum on day 2. The fibrotic change in the lung on day 28 was ameliorated by edaravone, as evaluated by histological examination and measurement of hydroxyproline contents. In addition, edaravone significantly increased the prostaglandin E2 concentration in BALF on day 2. In summary, edaravone was shown to inhibit lung injury and fibrosis via the repression of lipid hydroperoxide production and the elevation of prostaglandin E2 production in the present experimental murine system.