@article {Gren{\`e}che705, author = {J. Gren{\`e}che and M. Sar{\'e}mi and C. Erhardt and A. Hoeft and A. Eschenlauer and A. Muzet and P. Tassi}, title = {Severity of obstructive sleep apnoea/hypopnoea syndrome and subsequent waking EEG spectral power}, volume = {32}, number = {3}, pages = {705--709}, year = {2008}, doi = {10.1183/09031936.00117507}, publisher = {European Respiratory Society}, abstract = {It is well known that most patients with obstructive sleep apnoea/hypopnoea syndrome (OSAHS) suffer sleepiness, although the underlying mechanisms of this relationship remain unclear. The present study examined the relationship between nocturnal variables and the subsequent waking electroencephalogram (EEG), in order to determine if sleepiness was related to OSAHS severity and due to sleep fragmentation or to nocturnal hypoxaemia. In total, 12 moderate-to-severe OSAHS patients underwent a total sleep night followed by a 24-h period of sustained wakefulness where the waking EEG was measured every hour. The results showed that alpha (7.9{\textendash}12.6 Hz) and beta (12.7{\textendash}29.2 Hz) activities were strongly related to OSAHS severity, mainly reflected by the apnoea index. Moreover, spectral power in most of the waking EEG components was significantly correlated with nocturnal hypoxaemia indices, namely alpha and beta activity when hypoxaemia becomes severe. However, no correlation was found between the waking EEG and sleep fragmentation parameters. In conclusion, the present results suggest that the difficulty in maintaining an optimal level of alertness, reflected by a higher activity in awake alpha and beta bands (7.9{\textendash}29.2 Hz) in obstructive sleep apnoea/hypopnoea syndrome, was better explained by: 1) the apnoea as opposed to the hypopnoea index; and 2) nocturnal hypoxaemia as opposed to sleep fragmentation.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/32/3/705}, eprint = {https://erj.ersjournals.com/content/32/3/705.full.pdf}, journal = {European Respiratory Journal} }