PT  - JOURNAL ARTICLE
AU  - B Siebert
AU  - G Kunkel
AU  - K Borner
AU  - HW Staudinger
AU  - VW Steinijans
TI  - Efficacy of sustained release theophylline given at three different evening intake times in addition to a baseline medication
AID  - 10.1183/09031936.93.03020176
DP  - 1990 Feb 01
TA  - European Respiratory Journal
PG  - 176--181
VI  - 3
IP  - 2
4099  - http://erj.ersjournals.com/content/3/2/176.short
4100  - http://erj.ersjournals.com/content/3/2/176.full
SO  - Eur Respir J1990 Feb 01; 3
AB  - In this randomized crossover study of 26 outpatients with bronchial asthma the efficacy of a new once-daily theophylline formulation given in addition to a baseline medication was investigated; moreover, under steady state conditions, the effect of three evening intake times (6, 8 and 10 p.m.) on 24 h pharmacokinetics and peak-expiratory flow profiles was evaluated. The theophylline dose had been individually titrated. The pharmacodynamic results show a marked improvement of 24 h peak expiratory flow values after adding theophylline to a drug therapy including inhalative beta 2-agonists and corticosteroids in nearly all and inhalative anticholinergics in 50% of the treated outpatients. No significant differences between the pharmacokinetic characteristics and the 24 hr averages (mesors) of peak expiratory flow at the three different intake times 6, 8 and 10 p.m. were found; however, intake at 10 p.m. resulted in the highest nocturnal excess of serum theophylline concentrations and the highest peak expiratory flow during the early morning hours between 2 and 6 a.m.