PT  - JOURNAL ARTICLE
AU  - G. Zhang
AU  - C. M. Hayden
AU  - S-K. Khoo
AU  - P. Candelaria
AU  - I. A. Laing
AU  - S. Turner
AU  - P. Franklin
AU  - S. Stick
AU  - L. Landau
AU  - J. Goldblatt
AU  - P. N. Le Souëf
TI  - β<sub>2</sub>-Adrenoceptor polymorphisms and asthma phenotypes: interactions with passive smoking
AID  - 10.1183/09031936.00123206
DP  - 2007 Jul 01
TA  - European Respiratory Journal
PG  - 48--55
VI  - 30
IP  - 1
4099  - http://erj.ersjournals.com/content/30/1/48.short
4100  - http://erj.ersjournals.com/content/30/1/48.full
SO  - Eur Respir J2007 Jul 01; 30
AB  - The aim of the present study was to assess the effects of possible interactions between β2-adrenoceptor gene polymorphisms and passive smoking on forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and exhaled nitric oxide (eNO) in children aged 11 yrs. A cross-sectional analysis of the longitudinal cohort was conducted for associations between β2-adrenoceptor gene polymorphisms and lung function and eNO with regard to passive smoking. Among children exposed to tobacco smoke, those with Arg16 (at least one Arg allele) exhibited lower adjusted mean FEV1 (2.19 versus 2.38 L) and FVC (2.43 versus 2.64 L) than Gly16 homozygotes. Those with Gln27 (at least one Gln allele) also exhibited a lower adjusted mean FEV1 relative to Glu27 homozygotes (2.24 versus 2.39 L). Among children with no exposure to smoking, those with Arg16 or Gln27 showed lower adjusted geometric mean eNO levels compared with Gly16 homozygotes (15.4 versus 30.9 ppb) and Glu27 homozygotes (18.0 versus 49.7 ppb). In conclusion, passive smoking had a significant effect on associations between β2-adrenoceptor gene polymorphisms and asthma-related phenotypes, enhancing the relationship between Arg16 and lung function and removing the relationship between Arg16 or Gln27 and exhaled nitric oxide levels.