PT  - JOURNAL ARTICLE
AU  - C. Lafond
AU  - F. Sériès
AU  - C. Lemière
TI  - Impact of CPAP on asthmatic patients with obstructive sleep apnoea
AID  - 10.1183/09031936.00059706
DP  - 2007 Feb 01
TA  - European Respiratory Journal
PG  - 307--311
VI  - 29
IP  - 2
4099  - http://erj.ersjournals.com/content/29/2/307.short
4100  - http://erj.ersjournals.com/content/29/2/307.full
SO  - Eur Respir J2007 Feb 01; 29
AB  - The impact of continuous positive airway pressure (CPAP) treatment on the airway responsiveness of asthmatic subjects with obstructive sleep apnoea (OSA) has scarcely been studied. A prospective study was performed comparing the changes in airway responsiveness and quality of life in stable asthmatic OSA patients, before and 6 weeks after their nocturnal CPAP treatment. A total of 20 subjects (11 males and nine females) participated in the study. With the nocturnal CPAP treatment, the apnoea/hypopnoea index dropped from 48.1±23.6·h-1 to 2.6±2.5·h-1. There were no significant changes in airway responsiveness after CPAP treatment (provocative concentration causing a 20% fall in forced expiratory volume in one second (FEV1; PC20 2.5 mg·mL-1 (1.4–4.5)) compared with baseline (PC20 2.2 mg·mL-1 (1.3–3.5)). There was no significant change in FEV1 either. However, the asthma quality of life of the subjects improved from 5.0±1.2 at baseline to 5.8±0.9 at the end of the study. In conclusion, nocturnal continuous positive airway pressure treatment did not alter airway responsiveness or forced expiratory volume in one second in subjects with stable mild-to-moderate asthma and newly diagnosed obstructive sleep apnoea. However, nocturnal continuous positive airway pressure treatment did improve asthma quality of life.