TY - JOUR T1 - Interferon-γ therapy in two patients with progressive chronic pulmonary aspergillosis JF - European Respiratory Journal JO - Eur Respir J SP - 1307 LP - 1310 DO - 10.1183/09031936.06.00021705 VL - 27 IS - 6 AU - P. Kelleher AU - A. Goodsall AU - A. Mulgirigama AU - H. Kunst AU - D. C. Henderson AU - R. Wilson AU - A. Newman-Taylor AU - M. Levin Y1 - 2006/06/01 UR - http://erj.ersjournals.com/content/27/6/1307.abstract N2 - Infection by Aspergillus species causes a wide spectrum of pulmonary disease in humans. In two patients with semi-invasive Aspergillus-induced lung disease, significantly reduced levels of interferon-γ secretion by peripheral blood mononuclear cells were found after in vitro stimulation with the T-cell mitogen phytohaemagglutinin. Despite anti-fungal therapy, both patients exhibited progressive disease, and adjunctive interferon-γ therapy was associated with significant clinical improvement. The data suggest that impaired production of interferon-γ can be seen in patients with chronic pulmonary aspergillosis. Adjunctive cytokine therapy with interferon-γ may be useful in patients with progressive disease despite adequate anti-fungal therapy. ER -