RT Journal Article
SR Electronic
T1 Interferon-γ therapy in two patients with progressive chronic pulmonary aspergillosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1307
OP 1310
DO 10.1183/09031936.06.00021705
VO 27
IS 6
A1 P. Kelleher
A1 A. Goodsall
A1 A. Mulgirigama
A1 H. Kunst
A1 D. C. Henderson
A1 R. Wilson
A1 A. Newman-Taylor
A1 M. Levin
YR 2006
UL http://erj.ersjournals.com/content/27/6/1307.abstract
AB Infection by Aspergillus species causes a wide spectrum of pulmonary disease in humans. In two patients with semi-invasive Aspergillus-induced lung disease, significantly reduced levels of interferon-γ secretion by peripheral blood mononuclear cells were found after in vitro stimulation with the T-cell mitogen phytohaemagglutinin. Despite anti-fungal therapy, both patients exhibited progressive disease, and adjunctive interferon-γ therapy was associated with significant clinical improvement. The data suggest that impaired production of interferon-γ can be seen in patients with chronic pulmonary aspergillosis. Adjunctive cytokine therapy with interferon-γ may be useful in patients with progressive disease despite adequate anti-fungal therapy.