PT  - JOURNAL ARTICLE
AU  - Restrepo, M. I.
AU  - Mortensen, E. M.
AU  - Pugh, J. A.
AU  - Anzueto, A.
TI  - COPD is associated with increased mortality in patients with community-acquired pneumonia
AID  - 10.1183/09031936.06.00131905
DP  - 2006 Aug 01
TA  - European Respiratory Journal
PG  - 346--351
VI  - 28
IP  - 2
4099  - http://erj.ersjournals.com/content/28/2/346.short
4100  - http://erj.ersjournals.com/content/28/2/346.full
SO  - Eur Respir J2006 Aug 01; 28
AB  - Patients with chronic obstructive pulmonary disease (COPD) who develop community-acquired pneumonia (CAP) may experience worse clinical outcomes. However, COPD is not included as a distinct diagnosis in validated instruments that predict mortality in patients with CAP. The aim of the present study was to evaluate the impact of COPD as a comorbid condition on 30- and 90-day mortality in CAP patients. A retrospective observational study was conducted at two hospitals. Eligible patients had a discharge diagnosis and radiological confirmation of CAP. Among 744 patients with CAP, 215 had a comorbid diagnosis of COPD and 529 did not have COPD. The COPD group had a higher mean pneumonia severity index score (105±32 versus 87±34) and were admitted to the intensive care unit more frequently (25 versus 18%). After adjusting for severity of disease and processes of care, CAP patients with COPD showed significantly higher 30- and 90-day mortality than non-COPD patients. Chronic obstructive pulmonary disease patients hospitalised with community-acquired pneumonia exhibited higher 30- and 90-day mortality than patients without chronic obstructive pulmonary disease. Chronic obstructive pulmonary disease should be evaluated for inclusion in community-acquired pneumonia prediction instruments.