TY - JOUR T1 - Interstitial lung diseases associated with amyopathic dermatomyositis JF - European Respiratory Journal JO - Eur Respir J SP - 1005 LP - 1012 DO - 10.1183/09031936.06.00038806 VL - 28 IS - 5 AU - T. Suda AU - T. Fujisawa AU - N. Enomoto AU - Y. Nakamura AU - N. Inui AU - T. Naito AU - D. Hashimoto AU - J. Sato AU - M. Toyoshima AU - H. Hashizume AU - K. Chida Y1 - 2006/11/01 UR - http://erj.ersjournals.com/content/28/5/1005.abstract N2 - The aim of the present study was to clarify the clinical characteristics and prognosis of patients with interstitial lung disease (ILD) associated with amyopathic dermatomyositis (ILD-ADM). The study consisted of 14 consecutive patients with ILD-ADM. Patients were classified into two categories, acute/subacute and chronic forms, according to the clinical presentation of ILD. The clinical features, responsiveness to therapy, and prognosis between the two forms were compared. Nine ILD-ADM patients were categorised as the acute/subacute form, and five as the chronic form. Arterial oxygen tension was significantly lower in the acute/subacute ILD than chronic ILD patients. On high-resolution computed tomography, ground-glass opacities were frequently found in the two forms, but consolidation was more common in acute/subacute ILD than chronic ILD. Bronchoalveolar lavage analysis showed higher numbers of total cells and lymphocytes in acute/subacute ILD than chronic ILD. Histologically, the most common finding was nonspecific interstitial pneumonia in the two forms, while diffuse alveolar damage was only found in acute/subacute ILD. Acute/subacute ILD was generally resistant to therapy, while chronic ILD responded well. Notably, the mortality of acute/subacute ILD was much higher than that of chronic ILD (67 versus 0%, respectively). In conclusion, interstitial lung disease associated with amyopathic dermatomyositis includes two different forms, the acute/subacute and chronic forms, with distinct prognoses. ER -