RT Journal Article
SR Electronic
T1 Plasma fatty acids and lipid hydroperoxides increase after antibiotic therapy in cystic fibrosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 958
OP 964
DO 10.1183/09031936.00000906
VO 29
IS 5
A1 I. Durieu
A1 F. Abbas-Chorfa
A1 J. Drai
A1 J. Iwaz
A1 J-P. Steghens
A1 M. Puget
A1 R. Ecochard
A1 G. Bellon
YR 2007
UL http://erj.ersjournals.com/content/29/5/958.abstract
AB The present authors investigated whether cystic fibrosis is linked to a defect in fatty acids and assessed the impact of the main patients' characteristics on the levels of several fatty acids, mostly during respiratory exacerbation and after antibiotic therapy. Fatty acid phospholipid and cholesteryl ester levels were measured in stable-state patients and controls. No differences were found concerning either the fractions of palmitic and oleic acids or the cholesteryl esters of α-linolenic and arachidonic acids. However, phospholipids of α-linolenic and arachidonic acids, as well as cholesteryl esters and phospholipids of stearic and linoleic acids, were lower in patients than in controls, but fractions of dihomo-γ-linolenic, docosatetraenoic, docosapentaenoic, palmitoleic and eicosatrienoic acids were higher. Fatty acid levels, oxidative stress markers, nutrients, body mass index and forced expiratory volume in one second (FEV1) were measured in patients before and after antibiotic courses for bronchial exacerbation. After adjustments, palmitic, stearic, α-linolenic, linoleic, arachidonic, palmitoleic and oleic acids generally decreased during exacerbation but almost all increased after antibiotic courses. Nearly all fractions increased along with FEV1 and a positive relationship linked fatty acids to lipid hydroperoxides. There was no general drop in fatty acids. Patients' fatty acid profiles depended on the pulmonary function and the inflammation state.