PT - JOURNAL ARTICLE AU - S. Shah AU - M. Budev AU - H. Blazey AU - K. Fairbanks AU - A. Mehta TI - Hepatic veno-occlusive disease due to tacrolimus in a single-lung transplant patient AID - 10.1183/09031936.06.00048505 DP - 2006 May 01 TA - European Respiratory Journal PG - 1066--1068 VI - 27 IP - 5 4099 - http://erj.ersjournals.com/content/27/5/1066.short 4100 - http://erj.ersjournals.com/content/27/5/1066.full SO - Eur Respir J2006 May 01; 27 AB - Hepatic veno-occlusive disease is defined as nonthrombotic fibrous obliterative endophlebitis of small centrilobular hepatic venules. Clinically, patients present with elevated liver enzymes and a triad of jaundice, hepatomegaly and ascites. Although reported as a complication of other solid organ and stem cell transplantation, there have been no reported cases to date of veno-occlusive disease following lung transplantation. The present authors report a case of veno-occlusive disease following single-lung transplantation in a patient on a triple-drug immunosuppressive regimen composed of tacrolimus, mycophenolate mofetil and prednisone. The diagnosis was established by transjugular liver biopsy and by discontinuing tacrolimus; there was clinical regression of symptoms and serological return to baseline.