@article {Shah1066, author = {S. Shah and M. Budev and H. Blazey and K. Fairbanks and A. Mehta}, title = {Hepatic veno-occlusive disease due to tacrolimus in a single-lung transplant patient}, volume = {27}, number = {5}, pages = {1066--1068}, year = {2006}, doi = {10.1183/09031936.06.00048505}, publisher = {European Respiratory Society}, abstract = {Hepatic veno-occlusive disease is defined as nonthrombotic fibrous obliterative endophlebitis of small centrilobular hepatic venules. Clinically, patients present with elevated liver enzymes and a triad of jaundice, hepatomegaly and ascites. Although reported as a complication of other solid organ and stem cell transplantation, there have been no reported cases to date of veno-occlusive disease following lung transplantation. The present authors report a case of veno-occlusive disease following single-lung transplantation in a patient on a triple-drug immunosuppressive regimen composed of tacrolimus, mycophenolate mofetil and prednisone. The diagnosis was established by transjugular liver biopsy and by discontinuing tacrolimus; there was clinical regression of symptoms and serological return to baseline.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/27/5/1066}, eprint = {https://erj.ersjournals.com/content/27/5/1066.full.pdf}, journal = {European Respiratory Journal} }