TY - JOUR T1 - Time course of exhaled hydrogen peroxide and nitric oxide during chemotherapy JF - European Respiratory Journal JO - Eur Respir J SP - 1033 LP - 1039 DO - 10.1183/09031936.06.00101705 VL - 27 IS - 5 AU - A. R. Wewel AU - J. A. M. Crusius AU - U. Gatzemeier AU - M. Heckmayr AU - G. Becher AU - H. Magnussen AU - R. A. Jörres AU - O. Holz Y1 - 2006/05/01 UR - http://erj.ersjournals.com/content/27/5/1033.abstract N2 - This study was designed to assess the effect of differential leukocyte depletion during chemotherapy by monitoring the levels of exhaled hydrogen peroxide H2O2 and nitric oxide (FeNO) present. In 39 patients with lung cancer (chronic obstructive pulmonary disorder up to stage II, median forced expiratory volume in one second 78% predicted), measurements were performed before a cycle of therapy (day 1), at least once during the cycle (day 8: n = 34; day 15: n = 19), and afterwards (days 21–29). There were significant changes in the level of H2O2, FeNO and peripheral blood cell differentials over the visits. The level of H2O2 was decreased only on day 15, with a median (difference between the upper and lower quartiles) fall of 31 (57)%, while FeNO was reduced only on day 8, by 22 (40)%. Neutrophil numbers were unchanged on day 8 and decreased by 59 (48)% on day 15, while monocyte numbers were decreased on day 8 by 87 (39)%. On days 21–29, values had returned to baseline. Taken together with previous findings, the parallel course of levels of exhaled hydrogen peroxide and neutrophil counts suggests that a major part of exhaled hydrogen peroxide is due to neutrophils via the conducting airways. In contrast, the production of exhaled nitric oxide seems to be primarily associated with monocytes. ER -