RT Journal Article
SR Electronic
T1 Low-dose inhaled corticosteroids and the risk of acute myocardial infarction in COPD
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 634
OP 639
DO 10.1183/09031936.05.00079004
VO 25
IS 4
A1 L. Huiart
A1 P. Ernst
A1 X. Ranouil
A1 S. Suissa
YR 2005
UL http://erj.ersjournals.com/content/25/4/634.abstract
AB Inflammation plays a major role in the development and complications of atherosclerosis. Here, the dose-related impact of inhaled corticosteroids (ICS), used for their anti-inflammatory properties, on the risk of acute myocardial infarction (AMI) is studied in a cohort of chronic obstructive pulmonary disease (COPD) patients. Saskatchewan (Canada) health services databases were used to form a population-based cohort of 5,648 patients, ≥55 yrs, who received a first treatment for COPD between 1990 and 1997. A nested case-control analysis was conducted, where 371 cases presenting with a first AMI were matched with 1,864 controls, based on the date of cohort entry and age. A conditional logistic regression was used to estimate the effect of ICS, after adjusting for use of oral corticosteroids, severity of COPD, sex, systemic hypertension, diabetes and cardiovascular disease. ICS were used in the prior year by 42.2% of cases and 46.4% of controls. Overall, current use of ICS was not associated with a significant decrease in the risk of AMI. However, a 32% reduction in the risk of AMI was observed for doses ranging 50–200 µg·day−1. In conclusion, very low doses of inhaled corticosteroids may be associated with a reduction in the risk of acute myocardial infarction.