PT  - JOURNAL ARTICLE
AU  - Huiart, L.
AU  - Ernst, P.
AU  - Ranouil, X.
AU  - Suissa, S.
TI  - Low-dose inhaled corticosteroids and the risk of acute myocardial infarction in COPD
AID  - 10.1183/09031936.05.00079004
DP  - 2005 Apr 01
TA  - European Respiratory Journal
PG  - 634--639
VI  - 25
IP  - 4
4099  - http://erj.ersjournals.com/content/25/4/634.short
4100  - http://erj.ersjournals.com/content/25/4/634.full
SO  - Eur Respir J2005 Apr 01; 25
AB  - Inflammation plays a major role in the development and complications of atherosclerosis. Here, the dose-related impact of inhaled corticosteroids (ICS), used for their anti-inflammatory properties, on the risk of acute myocardial infarction (AMI) is studied in a cohort of chronic obstructive pulmonary disease (COPD) patients. Saskatchewan (Canada) health services databases were used to form a population-based cohort of 5,648 patients, ≥55 yrs, who received a first treatment for COPD between 1990 and 1997. A nested case-control analysis was conducted, where 371 cases presenting with a first AMI were matched with 1,864 controls, based on the date of cohort entry and age. A conditional logistic regression was used to estimate the effect of ICS, after adjusting for use of oral corticosteroids, severity of COPD, sex, systemic hypertension, diabetes and cardiovascular disease. ICS were used in the prior year by 42.2% of cases and 46.4% of controls. Overall, current use of ICS was not associated with a significant decrease in the risk of AMI. However, a 32% reduction in the risk of AMI was observed for doses ranging 50–200 µg·day−1. In conclusion, very low doses of inhaled corticosteroids may be associated with a reduction in the risk of acute myocardial infarction.