RT Journal Article SR Electronic T1 COPD: problems in diagnosis and measurement JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 4s OP 12s DO 10.1183/09031936.03.00077702 VO 21 IS 41 suppl A1 S.T. Weiss A1 D.L. DeMeo A1 D.S. Postma YR 2003 UL http://erj.ersjournals.com/content/21/41_suppl/4s.abstract AB Chronic obstructive pulmonary disease (COPD) is the most rapidly rising cause of death in individuals >65 yrs of age, the most rapidly growing segment of the USA population. Advancing the clinical research agenda for COPD entails careful consideration of several issues and problems: defining COPD, reliance on physiological testing, outcome measurements and comorbidities. In addition, issues pertaining to the recent dramatic increase in chronic obstructive pulmonary disease mortality in females, smoking susceptibility and the relationship of respiratory symptoms with hyperresponsiveness, as well as chronic obstructive pulmonary disease heterogeneity, are discussed.