RT Journal Article
SR Electronic
T1 Occupational and nonoccupational factors associated with high grade bronchial pre-invasive lesions
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 332
OP 341
DO 10.1183/09031936.03.00001503
VO 21
IS 2
A1 C. Paris
A1 J. Benichou
A1 S. Bota
A1 S. Sagnier
A1 J. Metayer
A1 S. Eloy
A1 J-B. Auliac
A1 G. Nouvet
A1 L. Thiberville
YR 2003
UL http://erj.ersjournals.com/content/21/2/332.abstract
AB Besides tobacco exposure, factors associated with the development of pre-invasive bronchial lesions are not known. Autofluorescence bronchoscopy was used to assess the prevalence of severe dysplasia and carcinoma in situ (SD/CIS) of the proximal bronchial tree in relation to occupational or nonoccupational carcinogen exposure. Among the 241 individuals in this study, the overall prevalence of at least one SD/CIS was 9% (21 subjects). Multivariable analysis revealed significant and independent associations between presence of SD/CIS and: 1) active smoking, relative to former smokers; 2) presence of synchronous invasive lung cancer; 3) duration of asbestos exposure and; 4) exposure to other occupational carcinogens. The independent associations of synchronous lung cancer with severe dysplasia and carcinoma, after adjusting for both occupational and nonoccupational carcinogen exposures, suggest other mechanisms than a field cancerisation may be involved in the carcinogenesis of these pre-invasive lesions. Moreover, active smokers, patients with recently resected invasive lung cancer and workers occupationally exposed to bronchial carcinogens may represent a population of choice for early cancer endoscopic detection programmes in view of their high severe dysplasia and carcinoma prevalence. This research was supported by a “Programme Hospitalier de Recherche Clinique” grant from the French Ministry of Research (1996).