PT  - JOURNAL ARTICLE
AU  - B. Chenuel
AU  - P. Haouzi
AU  - P. Olivier
AU  - P.Y. Marie
AU  - B. Chalon
AU  - J. Borrelly
TI  - Effect of exercise on lung-perfusion scanning in patients with bronchogenic carcinoma
AID  - 10.1183/09031936.02.00892001
DP  - 2002 Sep 01
TA  - European Respiratory Journal
PG  - 710--716
VI  - 20
IP  - 3
4099  - http://erj.ersjournals.com/content/20/3/710.short
4100  - http://erj.ersjournals.com/content/20/3/710.full
SO  - Eur Respir J2002 Sep 01; 20
AB  - The aim of this study was to determine whether perfusion-scintillation scanning, used as a predictive pre-operative index of lung functionality in patients with lung cancer, is affected by the level of pulmonary blood flow (PBF). Twenty patients with primary lung cancer underwent spirometry and a radionuclide-perfusion scan (macroaggregated albumin particles labelled with 99mTechnetium) both at rest and during the last minute of a ramp-like increase in work rate until exhaustion. On average, the perfusion of the lung with the tumour was significantly reduced by the same magnitude at rest and during exercise (mean±sd: −9±6% versus −10±4% of the cardiac output), regardless of the extent of the tumour. However, subject-by-subject analysis revealed that in two patients, a larger decrease in the perfusion of the lung with the tumour was observed during exercise than at rest (−11% and −17%, respectively). This leads to an underestimation of predictive postoperative functional parameters if resting values are used in these patients. The use of perfusion scintigraphy at rest therefore gives a clear picture of the functionality of the lung before resection in most patients requiring surgery.