TY - JOUR
T1 - Monitoring of nonlinear respiratory elastance using a multiple linear regression analysis
JF - European Respiratory Journal
JO - Eur Respir J
SP - 1158
LP - 1166
VL - 17
IS - 6
AU - Muramatsu, K.
AU - Yukitake, K.
AU - Nakamura, M.
AU - Matsumoto, I.
AU - Motohiro, Y.
Y1 - 2001/06/01
UR - http://erj.ersjournals.com/content/17/6/1158.abstract
N2 - The elastic pressure/volume (P/V) curve obtained by the multiple linear regression (MLR) technique using a new model, was compared with the quasi-static P/V points obtained by the rapid airway occlusion technique. Seven infants were studied during mechanical ventilation using a pressure controlled mode. The resistive pressure was subtracted from airway opening pressure, thus determining the elastance related pressure, which was then plotted against the volume to make an MLR-elastance curve. Quasi-static P/V curves of the rapid occlusion technique were constructed by plotting the different inspiratory and expiratory volumes against the corresponding values of the quasi-static airway pressure. The calculated MLR-elastance curves closely fit the experimental quasi-static P/V points obtained by the occlusion technique. There were, however, some discrepancies due to the viscoelastic behaviour of the respiratory system. Although slightly altered by these discrepancies, the multiple linear regression-elastance curves did fit the observed quasi-static pressure/volume characteristics for use in clinical practice. The multiple linear regression technique may prove to be clinically useful by continuous monitoring of respiratory system mechanics during mechanical ventilation.
ER -