TY - JOUR T1 - Monitoring of nonlinear respiratory elastance using a multiple linear regression analysis JF - European Respiratory Journal JO - Eur Respir J SP - 1158 LP - 1166 DO - 10.1183/09031936.01.00017801 VL - 17 IS - 6 AU - K. Muramatsu AU - K. Yukitake AU - M. Nakamura AU - I. Matsumoto AU - Y. Motohiro Y1 - 2001/06/01 UR - http://erj.ersjournals.com/content/17/6/1158.abstract N2 - The elastic pressure/volume (P/V) curve obtained by the multiple linear regression (MLR) technique using a new model, was compared with the quasi-static P/V points obtained by the rapid airway occlusion technique.Seven infants were studied during mechanical ventilation using a pressure controlled mode. The resistive pressure was subtracted from airway opening pressure, thus determining the elastance related pressure, which was then plotted against the volume to make an MLR-elastance curve. Quasi-static P/V curves of the rapid occlusion technique were constructed by plotting the different inspiratory and expiratory volumes against the corresponding values of the quasi-static airway pressure.The calculated MLR-elastance curves closely fit the experimental quasi-static P/V points obtained by the occlusion technique. There were, however, some discrepancies due to the viscoelastic behaviour of the respiratory system.Although slightly altered by these discrepancies, the multiple linear regression-elastance curves did fit the observed quasi-static pressure/volume characteristics for use in clinical practice. The multiple linear regression technique may prove to be clinically useful by continuous monitoring of respiratory system mechanics during mechanical ventilation. ER -