PT  - JOURNAL ARTICLE
AU  - J.M. Echave-Sustaeta
AU  - V. Villena
AU  - M. Verdugo
AU  - A. López-Encuentra
AU  - P. de Agustín
AU  - N. Alberti
TI  - X‐linked agammaglobulinaemia and squamous lung cancer
AID  - 10.1183/09031936.01.17305700
DP  - 2001 Mar 01
TA  - European Respiratory Journal
PG  - 570--572
VI  - 17
IP  - 3
4099  - http://erj.ersjournals.com/content/17/3/570.short
4100  - http://erj.ersjournals.com/content/17/3/570.full
SO  - Eur Respir J2001 Mar 01; 17
AB  - A 32 yr-old nonsmoking male, diagnosed as having X‐linked agammaglobulinemia, presented with fever, cough with purulent sputum, a very intense back pain and a mass of 10 centimetres in lower left lobe. Diagnostic evaluation revealed a squamous cell carcinoma with very aggressive metastases at L3. Malignancies are the second leading cause of death in children and adults with congenital immunodeficiency disorders, mostly non-Hodgkin lymphomas and gastric and colon adenocarcinomas, but this is the first report of lung cancer in a patient with X‐linked agammaglobulinemia. Lung cancer incidence has been reported to be higher in patients with other diseases of the lung, however, there is no clear evidence of the role of bronchiectasis in developing lung cancer. It is possible that a longer survival for patients with X‐LA recently diagnosed, and an association of chronic bronchial infection, could favour the development of pulmonary neoplasm.