RT Journal Article
SR Electronic
T1 Pulmonary toxicity with mefloquine
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 890
OP 892
VO 18
IS 5
A1 E. Udry
A1 F. Bailly
A1 M. Dusmet
A1 P. Schnyder
A1 R. Lemoine
A1 J.W. Fitting
YR 2001
UL http://erj.ersjournals.com/content/18/5/890.abstract
AB This report presents a case of acute lung injury developing within hours after administration of mefloquine for a low-level Plasmodium falciparum malaria, which was persistent despite halofantrine therapy. Extensive microbiological investigation remained negative and video-assisted thoracoscopic lung biopsy demonstrated diffuse alveolar damage. The evolution was favourable without treatment. This is the second report of acute lung injury and diffuse alveolar damage caused by mefloquine. Glucose-;6-;phosphate dehydrogenase deficiency was present in the former case and was thought to contribute to the lung injury. However, glucose-phosphate dehydrogenase was normal in the present case, suggesting that it is not a predisposing condition to the lung injury.