RT Journal Article
SR Electronic
T1 CO2 response and pattern of breathing in patients with symptomatic hyperventilation, compared to asthmatic and normal subjects
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 846
OP 851
DO 10.1183/09031936.93.01090846
VO 1
IS 9
A1 J Hormbrey
A1 MS Jacobi
A1 CP Patil
A1 KB Saunders
YR 1988
UL http://erj.ersjournals.com/content/1/9/846.abstract
AB We studied six patients with symptomatic hyperventilation, using new techniques to quantify baseline variability of respiratory variables, and to assess CO2 sensitivity around the control point using a stimulus not detectable by the subject. We compared them with six normal subjects and six patients with mild asthma. Symptomatic hyperventilators had normal mean ventilation and end-tidal carbon dioxide tension (PETCO2) at rest. Asthmatic subjects had higher ventilation and lower PETCO2. Symptomatic hyperventilators had a larger number of sighs and abnormally wide fluctuations in baseline for inspiratory time, expiratory time, and PETCO2. These could not be explained by an abnormal ventilatory response to a transient CO2 input; the transient response near the control point was undoubtedly normal.