RT Journal Article
SR Electronic
T1 The effect of prelung transplant clinical status on post-transplant survival of children with cystic fibrosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1061
OP 1064
DO 10.1034/j.1399-3003.2000.16f07.x
VO 16
IS 6
A1 P Aurora
A1 A Gassas
A1 S Ehtisham
A1 B Whitehead
A1 P Whitmore
A1 PG Rees
A1 VT Tsang
A1 MJ Elliott
A1 M de Leval
YR 2000
UL http://erj.ersjournals.com/content/16/6/1061.abstract
AB The aim of this study was to determine whether transplanting paediatric cystic fibrosis (CF) patients later in the course of their disease was detrimental to their post-transplant survival. Data was collected from 51 children with CF undergoing lung or heart-lung transplantation May 1988-March 1999. The following risk factors were tested by Cox proportional hazards modelling: age at transplant; sex; donor/recipient sex mismatch; donor/recipient cytomegalovirus (CMV) mismatch; cold and warm graft ischaemic times; and donor age. Pretransplant forced expiratory volume in one second (FEV1), minimum oxygen saturation obtained during 12 min walk (Sa,O2min), and a survival probability score (SP) calculated from FEV1, age adjusted resting heart rate, age, sex, blood haemoglobin (Hb), and serum albumin were then added to the model. None of the risk factors were significantly correlated with death during the study period. No evidence that clinical status prior to transplant has any effect upon the post-transplant survival of children with cystic fibrosis was found.