PT  - JOURNAL ARTICLE
AU  - K.I. Gaede
AU  - G. Wilke
AU  - L. Brade
AU  - H. Brade
AU  - M. Schlaak
AU  - J. Müller-Quernheim
TI  - Anti-Chlamydophila immunoglobulin prevalence in sarcoidosis and usual interstitial pneumoniae
AID  - 10.1183/09031936.02.00122002
DP  - 2002 Feb 01
TA  - European Respiratory Journal
PG  - 267--274
VI  - 19
IP  - 2
4099  - http://erj.ersjournals.com/content/19/2/267.short
4100  - http://erj.ersjournals.com/content/19/2/267.full
SO  - Eur Respir J2002 Feb 01; 19
AB  - Sarcoidosis and usual interstitial pneumoniae (UIP) are diseases of unknown aetiology affecting the lower respiratory tract. Although there are a number of studies investigating the causal role of these disorders, no micro-organism could be identified as the causal agent. The high incidence of Chlamydophila pneumoniae infections associated with lung injury encouraged the present investigations to screen patients with sarcoidosis and with UIP for their Chlamydophila-specific immune response. Thirty-nine patients with sarcoidosis, 26 patients with UIP and 34 controls were tested for the prevalence of Chlamydophila-specific antibodies in bronchoalveolar lavage fluids (BALF) and sera. Samples were tested for the presence of antibodies in a genus-specific test for Chlamydophila-lipopolysaccharide (LPS) and in a species-specific test for C. pneumoniae. This study revealed a significantly higher prevalence of Chlamydophila LPS-specific immunoglobulin (Ig)-G in the BALF of sarcoidosis patients (36.8%) compared to controls (8.8%) and patients with UIP (12.0%). Similar findings were observed in sera. The prevalence of C. pneumoniae-specific antibodies in BALF was significantly higher in sarcoidosis patients for IgG and IgA (IgG: 74.4%; IgA: 46.2%) and in UIP for IgG (IgG: 50.0%; IgA: 11.5%) compared to controls (IgG: 14.7%; IgA: 14.7%). The elevated prevalence of Chlamydophila-specific antibodies in sarcoidosis patients might implicate Chlamydophila as a causal agent. However, considering the high prevalence of Chlamydophila antibodies in the healthy population, the data presented might reflect Chlamydophila co-infections in pre-injured lungs seen in these patients.