@article {Adamicza975, author = {{\'A}. Adamicza and F. Pet{\'a}k and T. Asztalos and L. Tiszlavicz and M. Boros and Z. Hantos}, title = {Endothelin-1-induced airway and parenchymal mechanical responses in guinea-pigs: the roles of ETA and ETB receptors}, volume = {17}, number = {5}, pages = {975--981}, year = {2001}, doi = {10.1183/09031936.01.17509750}, publisher = {European Respiratory Society}, abstract = {Endothelin-1 (ET-1) has been shown to have a constrictor effect on the airways and parenchyma; however, the roles of the ETA and ETB receptors in the ET-1-induced changes in the airway and tissue compartments have not been fully explored.Low-frequency pulmonary impedance (ZL) was measured in anaesthetized, paralysed, open-chest guinea-pigs. ZL spectra were fitted by a model to estimate airway resistance (Raw) and inertance (Iaw), and coefficients of tissue damping (G) and elastance (H), and hysteresivity (η=G/H).Two successive doses of ET-1 (0.05 and 0.2 nmol{\textperiodcentered}kg-1) each evoked significant dose-related increases in Raw, G, H and η. Pretreatment with 20 nmol{\textperiodcentered}kg-1 BQ-610 (a highly selective ETA receptor antagonist) resulted in a significantly decreased elevation only in H after the lower dose of ET-1. However, all parameters changed significantly less on the administration of ET-1 after pretreatment with 80 nmol{\textperiodcentered}kg-1 BQ-610, with 20 nmol{\textperiodcentered}kg-1 ETR-P1/fl (a novel ETA receptor antagonist) or with 20 nmol{\textperiodcentered}kg-1 IRL 1038 (an ETB receptor antagonist).The results of the separate assessments of the airway and tissue mechanics demonstrate that endothelin-1 induces airway and parenchymal constriction via stimulation of both receptor types in both compartments.This study was supported by Hungarian Scientific Research Fund grants T30670 and T023089.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/17/5/975}, eprint = {https://erj.ersjournals.com/content/17/5/975.full.pdf}, journal = {European Respiratory Journal} }