PT  - JOURNAL ARTICLE
AU  - Nishino, T
AU  - Isono, S
AU  - Ide, T
TI  - Effects of negative pressure assisted ventilation on dyspnoeic sensation and breathing pattern
AID  - 10.1183/09031936.98.12061278
DP  - 1998 Dec 01
TA  - European Respiratory Journal
PG  - 1278--1283
VI  - 12
IP  - 6
4099  - http://erj.ersjournals.com/content/12/6/1278.short
4100  - http://erj.ersjournals.com/content/12/6/1278.full
SO  - Eur Respir J1998 Dec 01; 12
AB  - Although negative pressure assisted ventilation with an assist-control mode may have a potential therapeutic role in the treatment of severe dyspnoea, the effects of negative pressure assisted ventilation with the assist-control mode on dyspnoea and breathing patterns have not been examined. We examined the effects of negative pressure assisted ventilation with the assist-control mode on dyspnoea and breathing patterns produced by a combination of resistive loading and hypercapnia in nine healthy subjects breathing spontaneously. Subjects were asked to rate their sensation of respiratory discomfort using a visual analogue scale. Negative pressure assisted ventilation caused a significant reduction in sensation of respiratory discomfort from a visual analogue scale score of 74 (55-91) (median (range)) before negative pressure assisted ventilation to 34 (15-53) during negative pressure assisted ventilation (p<0.01). During negative pressure assisted ventilation, there were significant changes in breathing patterns characterized by an increase in tidal volume and a decrease in respiratory frequency, while neither minute ventilation nor end-tidal carbon dioxide tension changed. Our results indicate that negative pressure assisted ventilation with the assist-control mode is effective in relief of dyspnoea and that negative pressure assisted ventilation influences the control of breathing to minimize respiratory discomfort.