RT Journal Article
SR Electronic
T1 Sensitivity and exposure to indoor allergens in adults with differing asthma severity
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 654
OP 659
DO 10.1183/09031936.99.13365499
VO 13
IS 3
A1 WS Tunnicliffe
A1 TJ Fletcher
A1 K Hammond
A1 K Roberts
A1 A Custovic
A1 A Simpson
A1 A Woodcock
A1 JG Ayres
YR 1999
UL http://erj.ersjournals.com/content/13/3/654.abstract
AB In asthma, it is uncertain whether there is an association between degrees of exposure to domestic allergens and asthma severity. The pattern of sensitivity and exposure to common indoor allergens was examined in subjects with differing asthma severity. Sensitivity to house dust mite, dog and cat allergen and exposure to Der p 1, Can f 1 and Fel d 1 were assessed by skin prick tests and settled dust analysis in 28 subjects with severe asthma and 28 age- and sex-matched subjects with mild asthma (two declined skin prick test). All severe asthmatic subjects had at least one positive skin test and 20 of the 28 subjects were positive to all three allergens. Fourteen of the 26 subjects with mild asthma who took skin prick tests were positive to at least one, and one of these subjects was positive to the three allergens tested. Except for bedroom Fel d 1, the proportion of severe asthmatics both sensitized and exposed to each allergen at each site was significantly greater than the proportion sensitized and exposed in the mild asthma group. The geometric mean allergen concentrations, with the exception of bedroom Fel d 1, were greater in sensitized severe asthmatics than the sensitized mild asthmatics, which was significant for Der p 1 in bedroom samples and Can f 1 in bedroom and living room samples. These results support an association between the degrees of domestic allergen exposure in sensitized individuals and asthma severity.