TY - JOUR T1 - Maximum rate of change in oesophageal pressure assessed from unoccluded breaths: an option where mouth occlusion pressure is impractical JF - European Respiratory Journal JO - Eur Respir J SP - 693 LP - 697 DO - 10.1183/09031936.98.12030693 VL - 12 IS - 3 AU - CH Hamnegard AU - MI Polkey AU - D Kyroussis AU - GH Mills AU - M Green AU - B Bake AU - J Moxham Y1 - 1998/09/01 UR - http://erj.ersjournals.com/content/12/3/693.abstract N2 - The mouth occlusion pressure 100 ms after onset of inspiration (P0.1) is considered a clinically useful measure of the combined output of the respiratory centre and muscle pump. However, theoretical and practical difficulties can arise when using P0.1 in the assessment of patients with severe chronic obstructive pulmonary disease (COPD). It was hypothesized that the maximum rate of change in oesophageal pressure (dPoes,max/dt) may be an alternative to P0.1. To test this hypothesis P0.1 was compared with mean dPoes,max/dt measured from neighbouring unoccluded breaths in five normal subjects during CO2 rebreathing. In all subjects a close correlation was found between both dPoes,max/dt and P0.1 and carbon dioxide tension (PCO2). In six patients with severe COPD performing exhaustive treadmill walks, dPoes,max/dt was found to increase progressively with walking time. Mean dPoes,max/dt at the start was 6.2 cmH2O x 100 ms(-1) and at the finish was 18.7 cmH2O x 100 ms(-1) (p<0.03). In conclusion, the maximum rate of change in oesophageal pressure measured from unoccluded breaths could be an alternative in circumstances where it is not feasible to use measurements of the mouth occlusion pressure 100 ms after onset of inspiration. ER -