RT Journal Article
SR Electronic
T1 Inhaled corticosteroids and Churg-Strauss syndrome: a report of five cases
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 978
OP 981
DO 10.1034/j.1399-3003.2000.15e29.x
VO 15
IS 5
A1 C Le Gall
A1 S Pham
A1 S Vignes
A1 G Garcia
A1 H Nunes
A1 D Fichet
A1 G Simonneau
A1 P Duroux
A1 M Humbert
YR 2000
UL http://erj.ersjournals.com/content/15/5/978.abstract
AB Churg-Strauss syndrome is an eosinophil-associated, small vessel granulomatous vasculitis, characterized by late onset asthma, upper airways disease, eosinophilia, and clinical manifestations of systemic vasculitis. Several cases of Churg-Strauss syndrome have been recognized in patients treated with cysteinyl leukotriene-receptor antagonists and weaned off systemic corticosteroids. These cases have led to a general warning on the possible development of Churg-Strauss syndrome after taking cysteinyl leukotriene-receptor antagonists. The authors report five cases of Churg-Strauss syndrome in severe steroid dependent asthmatics in whom inhaled corticosteroids allowed systemic corticosteroid withdrawal. It is concluded that physicians should monitor patients carefully when severe asthma is controlled with any substance allowing withdrawal from (or even avoidance) of systemic corticosteroids. Case-control studies should identify more precisely the risk factors of Churg-Strauss syndrome.