RT Journal Article
SR Electronic
T1 Acute allergic reaction and demonstration of specific IgE antibodies against alpha-1-protease inhibitor
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 996
OP 997
DO 10.1183/09031936.98.12040996
VO 12
IS 4
A1 Meyer, FJ
A1 Wencker, M
A1 Teschler, H
A1 Steveling, H
A1 Sennekamp, J
A1 Costabel, U
A1 Konietzko, N
YR 1998
UL http://erj.ersjournals.com/content/12/4/996.abstract
AB A 44 yr-old female with severe pulmonary emphysema and reduced alpha-1-protease inhibitor (alpha1-PI) serum levels developed an acute anaphylactic reaction following the third intravenous infusion of human alpha1-PI which was administered to prevent the progression of pulmonary emphysema. Specific immunoglobulin E-antibodies against human alpha1-PI could be demonstrated in the patient's serum using an enzyme allergosorbent test. Because of the risk of further severe anaphylactic reaction, the replacement therapy with alpha1-PI was discontinued. Physicians should be aware of this rare complication.