PT  - JOURNAL ARTICLE
AU  - Meyer, FJ
AU  - Wencker, M
AU  - Teschler, H
AU  - Steveling, H
AU  - Sennekamp, J
AU  - Costabel, U
AU  - Konietzko, N
TI  - Acute allergic reaction and demonstration of specific IgE antibodies against alpha-1-protease inhibitor
AID  - 10.1183/09031936.98.12040996
DP  - 1998 Oct 01
TA  - European Respiratory Journal
PG  - 996--997
VI  - 12
IP  - 4
4099  - http://erj.ersjournals.com/content/12/4/996.short
4100  - http://erj.ersjournals.com/content/12/4/996.full
SO  - Eur Respir J1998 Oct 01; 12
AB  - A 44 yr-old female with severe pulmonary emphysema and reduced alpha-1-protease inhibitor (alpha1-PI) serum levels developed an acute anaphylactic reaction following the third intravenous infusion of human alpha1-PI which was administered to prevent the progression of pulmonary emphysema. Specific immunoglobulin E-antibodies against human alpha1-PI could be demonstrated in the patient's serum using an enzyme allergosorbent test. Because of the risk of further severe anaphylactic reaction, the replacement therapy with alpha1-PI was discontinued. Physicians should be aware of this rare complication.