TY - JOUR T1 - Effects of high-altitude periodic breathing on sleep and arterial oxyhaemoglobin saturation JF - European Respiratory Journal JO - Eur Respir J SP - 408 LP - 413 DO - 10.1183/09031936.98.12020408 VL - 12 IS - 2 AU - A Salvaggio AU - G Insalaco AU - O Marrone AU - S Romano AU - A Braghiroli AU - P Lanfranchi AU - V Patruno AU - CF Donner AU - G Bonsignore Y1 - 1998/08/01 UR - http://erj.ersjournals.com/content/12/2/408.abstract N2 - This study aimed to investigate the effect of periodic breathing (PB) at high altitude on sleep structure and arterial oxygen saturation (Sa,O2). Five healthy subjects underwent polysomnographic studies at sea level, and during the first and the fourth week of sojourn at 5,050 m. Their breathing pattern, sleep architecture and Sa,O2 were analysed. PB was detected in the high-altitude studies during nonrapid eye movement (NREM) sleep and tended to increase from the first to the fourth week. Stages 3-4 were absent in four subjects at the first week, but only in one at the fourth week, irrespective of the amount of PB. The arousal index was 11.6+/-3.8 at sea level, 30.1+/-15.5 at the first week at altitude and 33.0+/-18.2 at the fourth week. At altitude, arousal index in NREM sleep was higher during PB than during regular breathing. In NREM sleep, the mean highest Sa,O2 levels in NREM epochs with PB were higher than in those with regular breathing by 2.8+/-1.7% at the first week and 2.9+/-1.5% at the fourth week (p<0.025). From the first to the fourth week, mean Sa,O2 increased significantly during wakefulness (5.6%), NREM (5.2% with regular breathing and 5.3% with PB) and rapid eye movement sleep (7.6%). The data demonstrate a slight role of periodic breathing in altering sleep architecture at high altitude and also show that periodic breathing induces only a minor improvement in arterial oxygen saturation during nonrapid eye movement sleep. ER -