TY - JOUR T1 - Talc-induced inflammation in the pleural cavity JF - European Respiratory Journal JO - Eur Respir J SP - 1419 LP - 1423 DO - 10.1183/09031936.98.12061419 VL - 12 IS - 6 AU - MM van den Heuvel AU - HJ Smit AU - SB Barbierato AU - CE Havenith AU - RH Beelen AU - PE Postmus Y1 - 1998/12/01 UR - http://erj.ersjournals.com/content/12/6/1419.abstract N2 - Talc administration into the pleural cavity induces pleurodesis. To obtain further insight into the inflammatory process that causes pleurodesis, the cellular kinetics in the pleural space after the administration of talc was studied, along with its relation to chemokine concentrations in the pleural fluid. Thirteen consecutive patients with idiopathic spontaneous pneumothorax and eight patients with malignant pleural effusions received talc pleurodesis. The first group was treated with talc poudrage, whereas the second group was treated with talc slurry. Pleural fluids were isolated before talc administration as well as 3, 6, 24, 48 and 72 h afterwards. The talc induced a rapid polymorphonuclear neutrophil (PMN) influx followed by an accumulation of macrophages. In addition, increased production of interleukin (IL)-8 and monocyte chemotactic protein (MCP)-1 was observed. The talc-induced PMN influx reached its maximum after 3-24 h, and was related to the IL-8 concentration. In contrast, the MCP-1 was not related to the macrophage accumulation. Talc-induced inflammation in patients with idiopathic spontaneous pneumothorax and malignant pleural effusion is characterized by an influx of polymorphonuclear neutrophils related to interleukin-8, followed by an accumulation of monocytes. ER -