RT Journal Article
SR Electronic
T1 Nocturnal asthma: effects of slow-release terbutaline on spirometry and arterial blood-gases
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 302
OP 305
DO 10.1183/09031936.93.01040302
VO 1
IS 4
A1 Eriksson, L
A1 Jonson, B
A1 Eklundh, G
A1 Persson, G
YR 1988
UL http://erj.ersjournals.com/content/1/4/302.abstract
AB The effect of terbutaline, in a slow-release preparation, on spirometry and arterial blood-gases, was studied in fourteen patients with nocturnal asthma. The patients were treated with either 15 mg of slow-release terbutaline or placebo given as a single dose at 10 pm for eight days in a double-blind crossover trial. The patients were studied in the hospital for one night at the end of each treatment period. During active treatment the patients had a significantly higher FEV1 and PaO2 compared with placebo. Tolerance to the high single dose was good and none of the patients discontinued treatment because of side-effects. In patients with nocturnal asthma treatment with a high dose of slow-release terbutaline given as a single dose in the evening appears to be effective.