TY - JOUR T1 - Alpha-fetoprotein producing pulmonary blastoma in a patient with systemic sclerosis: pathogenetic analysis JF - European Respiratory Journal JO - Eur Respir J SP - 1185 LP - 1187 DO - 10.1183/09031936.98.11051185 VL - 11 IS - 5 AU - I Kasuga AU - D Miyamoto AU - Y Ichinose AU - W Chimangul AU - K Minemura AU - K Utsumi AU - M Yonemaru AU - H Serizawa AU - Y Ebihara AU - K Toyama Y1 - 1998/05/01 UR - http://erj.ersjournals.com/content/11/5/1185.abstract N2 - We describe a rare case of pulmonary blastoma complicated with systemic sclerosis. The serum alpha-fetoprotein level was elevated at presentation and the biopsied tumour stained positively against anti-alpha-fetoprotein antibody. The alpha-fetoprotein produced autonomously by tumour cells was of yolk-sac origin. Although the pathogenesis of pulmonary blastoma has not been clarified, we suggest that this pulmonary blastoma is a type of yolk-sac tumour. ER -