PT  - JOURNAL ARTICLE
AU  - P Herve
AU  - D Lebrec
AU  - F Brenot
AU  - G Simonneau
AU  - M Humbert
AU  - O Sitbon
AU  - P Duroux
TI  - Pulmonary vascular disorders in portal hypertension
AID  - 10.1183/09031936.98.11051153
DP  - 1998 May 01
TA  - European Respiratory Journal
PG  - 1153--1166
VI  - 11
IP  - 5
4099  - http://erj.ersjournals.com/content/11/5/1153.short
4100  - http://erj.ersjournals.com/content/11/5/1153.full
SO  - Eur Respir J1998 May 01; 11
AB  - The wide spectrum of pulmonary vascular disorders in liver disease and portal hypertension ranges from the hepatopulmonary syndrome characterized by intrapulmonary vascular dilatations, to pulmonary hypertension (portopulmonary hypertension), in which pulmonary vascular resistance is elevated. Since hepatopulmonary syndrome and portopulmonary hypertension have been reported in patients with nonhepatic portal hypertension, the common factor that determines their development must be portal hypertension. The clinical presentations are very different, with gas exchange impairment in the hepatopulmonary syndrome and haemodynamic failure in portopulmonary hypertension. The severity of hepatopulmonary syndrome seems to parallel the severity of liver failure, whereas no simple relationship has been identified between hepatic impairment and the severity of portopulmonary hypertension. Resolution of hepatopulmonary syndrome is common after liver transplantation, which has an uncertain effect in portopulmonary hypertension. The pathophysiology of both syndromes may involve vasoactive mediators and angiogenic factors.